What is Sermorelin? Why choose Sermorelin? These are common questions and we have the answers! Below is a question and answer forum conducted with Dr. of Applied Research in Aging (SARA-International) in which he supplies answers to the most common questions about Sermorelin.
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Question: What is Sermorelin? I see that it is sometimes called GRF 1-29 NH 2. Since GRF means growth hormone releasing factor, is Sermorelin the same molecule as that which is produced by the brain to stimulates pituitary gland production and secretion of HGH?
Dr. : Sermorelin is a form of GRF that contains only the first 29 amino acids. GRF that is produced by neurosecretory neurons in the brain contains 44 amino acids. When the structure of GRF was first described by the Nobel Laureates, R. Guilleman and A. Shalley in the 1970's one of their students, William Wehrenberg sought to determine which part of the HGH molecule was essential for its pituitary stimulating action. By eliminating individual amino acids and then testing the remaining peptide, he found that only the first 29 amino acids are responsible for stimulating pituitary production and secretion of HGH. Therefore, the chemical name for Sermorelin is GRH 1-29 NH 2 . The NH 2 is included in the name so as to indicate the amino terminus of the molecule.
Question: Is Sermorelin the same thing as human growth hormone (HGH)?
Dr. : No, it is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete HGH. Sermorelin is a small peptide containing only 29 amino acids whereas HGH is a much larger molecule containing 191 amino acids.
Question: I've seen advertisements for HGH secretagogues that do not require a prescription. Are these the same as Sermorelin?
Dr. : No, the OTC secretagogues or releasers are usually the amino acids L-arginine, L-glutamine, L-ornithine, glycine, L-dopa, as well as such substances as ornithine alpha-ketoglutarate and the herbs Macuna pruriens and Tribulus terrestris . While high doses of these compounds sometimes elicit release of HGH from the pituitary gland, the effect is non-specific. In other words, they create a general effect on brain activity, just as exercise does, that sometimes causes HGH to be released. However, the effect is intermittent and unreliable since it does not work through any receptor specific process on the pituitary gland. Also, high doses of amino acids can produce kidney problems presenting a risk for the regular use of such products. In contrast, Sermorelin has highly specific and saturable receptors on pituitary somatotrophs. Thus, it binds to the cells that produce and release HGH. Upon binding, Sermorelin initiates its action through a cylicAMP second messenger system exactly the same as that used by naturally occurring growth hormone releasing hormone. Furthermore, it has an excellent safety profile with little side effects.
Question: If HGH is effective in addressing adult growth hormone deficiency, why should I consider prescribing Sermorelin?
Dr. : For several reasons including the fact that it produces the same effects on body composition and other benefits of HGH but in addition:
It's effects are regulated at the level of the pituitary gland by negative feedback and by release of somatostatin so that safety concerns associated the HGH overdosing are minimized or completely avoided, Tissue exposure to HGH released by the pituitary under the influence of Sermorelin is episodic not “square wave” preventing tachphylaxis by mimicking normal physiology, By stimulating the pituitary it preserves more of the growth hormone neuroendocrine axis that is the first to fail during aging, Pituitary recrudescence resulting from Sermorelin blocks the cascade of hypophyseal hormone failure that occurs during aging thereby preserving not only youthful anatomy but also youthful physiology, It provides the patient with all the benefits and more of HGH replacement therapy and furthermore, its OFF LABEL USE IS NOT PROHIBITED BY FEDERAL LAW. Question: Must Ser
morelin be injected just as is required for HGH?
Dr. : Currently, the only method for effectively administering Sermorelin is by subcutaneous injection. However, because the molecule is much smaller than HGH, it may be possible to successfully administer it through the nasal mucousa using a spray formulation. This hypothesis is currently being tested clinically and the results should soon be known.
Question: Are the effective dosages of HGH and Sermorelin comparable?
Dr. : Although the molecules work at different sites in the body (HGH at the liver and Sermorelin at the pituitary), the amount of material needed to be effective in raising serum IGF-1 are approximately the same. HGH is generally prescribed in daily doses of one or two international units (IU) while Sermorelin is prescribed in micrograms. However, one IU is equal to 333 micrograms so the weight of effective dosages is approximately between 300 and 600 micrograms per day. The recommended dosages for Sermorelin are between 200 to 500 micrograms per day; a range which is comparable to that for HGH.